A surprising finding by DiGabriele et al. 16 is that FGF-1 can bind heparin irrespective of the orientation of the glycosaminoglycan. In fact, as discussed below, the protomers within each FGF-1 ...

Specifically we have been interested in characterizing the role of Wnt and Fgf family members in normal mammary gland development and stem cell self-renewal, and the properties of tumor initiating ...

Use of dominant negative and activated receptors to determine the biological effects of FGF receptor activation and inactivation in prostate cancer cell lines and analysis of the signal transduction ...

regenerative medicine and material preparation, clinical pharmacology and toxicology, drug analysis, and metabolomics. Research by the FGF team has led to a series of novel drugs, including three ...