This intricate process allows bile acids to function beyond digestion as metabolic regulators. However, disruptions in this circuit can lead to gastrointestinal diseases, making bile acids a critical ...

Scientists have identified new ways in which bile acids interact with cellular stress responses, impacting how the liver functions in diseases like cholestasis, fatty liver disease (MASLD), and ...

"Some microbial bile acids support FXR's function, while others antagonize it," says Ting Fu, an assistant professor in the UW–Madison School of Pharmacy. Fu and her colleagues previously ...

Bile reflux gastritis (BRG) is a gastro-intestinal condition especially characterized by the reflux of bile into the stomach, further leading to mucosal inflammation along with various other clinical ...

In addition, surrogate markers of efficacy, such as standard liver function tests and liver histology ... assessment. Novel bile acids and biological agents that are specifically designed to ...