A number of cell surface and nuclear receptors mediate their actions via dimerization. While this has been well established, the dimerization of G-protein coupled receptors (GPCRs) (that ...

The process involves adding a fluorescent or radioactive tag to make a target compound stand out during testing.

例如G蛋白偶联受体(G protein-coupled receptor，GPCR)和离子通道在PDB等数据库中未得到充分代表，而且药物发现相关数据集可能存在高度不平衡的情况[27]。因此在评估模型时需要获取合适的数据集，合适的数据平衡方法以及合适的衡量指标。 AI辅助药物研发的另一个 ...

While treating chronic pain with opioids is still challenging thanks to the risk of severe side effects as well as dependency ...

An estimated one in five Americans live with chronic pain and current treatment options leave much to be desired. Feixiong ...

GlobalData’s report assesses the drugs in the Apelin Receptor pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline.

Thirtyfivebio Ltd. has described G protein-coupled receptor GPR35 antagonists reported to be useful for the treatment of cancer, fibrosis, inflammatory, cardiovascular, gastrointestinal and ...

An estimated one in five Americans live with chronic pain and current treatment options leave much to be desired. Scientists are now using artificial intelligence (AI) for drug discovery in advanced ...

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Chemokines are a subclass of ...

More information: Ruxandra Barzan et al, Gain control of sensory input across polysynaptic circuitries in mouse visual cortex by a single G protein-coupled receptor type (5-HT2A), Nature ...

Owino’s primary research focuses on receptor signaling mechanisms underlying central nervous system plasticity following stroke. Her lab utilizes transgenic mice and various cellular models to explore ...