G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

A basic function of cells is that they act in response to their environments. It makes sense, then, that a goal of scientists ...

A team of scientists led by Professor Annette Beck-Sickinger from the Institute of Biochemistry at Leipzig University has ...

Now, detailed in a paper published Dec. 4 in Nature, Stanford researchers have developed a new synthetic receptor that accommodates a broader range of inputs and produces a more diverse set of outputs ...

A basic function of cells is that they act in response to their environments. It makes sense, then, that a goal of scientists ...

GPR6, a G protein-coupled receptor, is primarily expressed in the medium spiny neurons of the striatum, specifically within ...

Researchers have identified a natural substance, hederagenin, that blocks the NPFFR1 receptor, a protein involved in pain perception in the brain and spinal cord.

This innovation, called "Programmable Antigen-gated G protein-coupled Engineered Receptors" (PAGER), is built around G protein-coupled receptors, a set of over 800 proteins in the human body that ...

University of Southern California-led researchers have discovered the structural details of a brain receptor called GPR6, ...

HETE is the endogenous agonist for G protein-coupled receptor 39 (GPR39) in vascular smooth cells, so researchers ...