G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

G-protein coupled receptors regulate hormone secretions in the pancreas. Learn how the complex signaling features of these receptors are illuminating diabetes research. Diabetes results from ...

The process involves adding a fluorescent or radioactive tag to make a target compound stand out during testing.

An estimated one in five Americans live with chronic pain and current treatment options leave much to be desired. Feixiong ...

the research team noted that evidence has demonstrated that drugging a specific subset of pain receptors in a protein class ...

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Chemokines are a subclass of ...

This manuscript describes a valuable study of a new lipid-mediated regulation mechanism of adenylyl cyclases. The biochemical evidence provided is convincing, but more evidence for regulation by ...

An estimated one in five Americans live with chronic pain and current treatment options leave much to be desired. Scientists are now using artificial intelligence (AI) for drug discovery in advanced ...

The acquisition will add a late-stage drug candidate with blockbuster potential to Lundbeck’s neuroscience pipeline.

GlobalData’s report assesses the drugs in the Apelin Receptor pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline.

More information: Ruxandra Barzan et al, Gain control of sensory input across polysynaptic circuitries in mouse visual cortex ...