如今，在一项新的研究中，来自加州大学圣地亚哥分校和德克萨斯大学西南医学中心的研究人员构建了人类大脑中GABA A 受体的详细结构图，揭示了它们是如何组装的，以及药物是如何与它们结合的。相关研究结果近期发表在 Nature 期刊上，论文标题为 “Resolving native GABAA receptor structures from the human brain”。

Protein-protein interactions govern a large number of biological processes. A number of cell surface and nuclear receptors mediate their actions via dimerization. While this has been well ...

γ-aminobutyric acid (GABA), whether it be lower levels of GABA or the receptor it binds to. But a study published last week (October 3) in Science Translational Medicine, which zeroed in on GABA ...

The researchers also used electrophysiology to measure how GABA A receptors function and respond to drugs. The results allowed the scientists to create a detailed map of GABA A receptors ...

Until recently, it has largely been assumed that G protein-coupled receptors (GPCRs) function as monomeric entities. However, over the past few years, we and others have documented that GPCRs can ...

The researchers also used electrophysiology to measure how GABA A receptors function and respond to drugs. The results allowed the scientists to create a detailed map of GABA A receptors ...

Unlike many existing drugs that target beta-amyloid buildup, GL-II-73 selectively targets GABA receptors in the hippocampus to restore brain function and repair damaged neural connections. Early ...

The researchers reported that they have already discovered novel functions for two epilepsy drugs previously not known to act on GABA A receptors. "This research helps explain how the brain's ...

This protein not only amplifies alcohol’s action on GABA receptors—key players ... alteration of TMEM132B affected brain activity, receptor function, and alcohol-related behaviors.

Overexpression of either of two GABA receptor types compensated for the loss of the other, suggesting that these two receptors can function in a similar way in the SCN, even though they have been ...