Spinogenix is using small molecule drugs to regenerate synapses in patients with ALS, Alzheimer's disease, schizophrenia, ...

Glutamatergic synapses in particular can be viewed as one of the most complex subcellular specializations in the entire body.” To grapple with these complexities, the company is developing first ...

Spinogenix, Inc., a clinical-stage biopharmaceutical company pioneering first-in-class therapeutics that restore synapses to ...

Whereas the specific type and number of glutamate receptors at glutamatergic synapses must be precisely regulated, the mechanisms underlying glutamate receptor targeting and stabilization are not ...

Our research supports that GluA4 subunit confers a minimal mechanism for activity-dependent AMPA-receptor regulation to facilitate plasticity during early development of glutamatergic synapses.

A wealth of data from histological, imaging, genetic and other studies implicate a loss of glutamatergic synapses in frontal cortex and other regions as a primary feature of schizophrenia ...

Richard Lounsbery Award recipient, will present the 2024 Lounsbery Lecture on "Neuron-glial Interactions in Health and ...

By studying the synapses through which pyramidal neurons in the brain's sensory cortex communicate, they have learned how the ...