Studies over more than a decade have generated a picture of how the external Env subunit (gp120) interacts first with the primary receptor (CD4) and then with a co-receptor (a chemokine receptor ...

The study shows that intact HIV and its viral envelope protein gp120 each cause macrophages, a type of white blood cell, to ...

REVELATION: The glycoprotein gp120 binds to the CD4 receptor on the T cell, causing the viral molecule to contort in a way that enables it to bind to the nearby chemokine receptor, too. This dual ...

One fusion inhibitor (enfuvirtide, also known as Fuzeon) is available, but is rarely used. Attachment inhibitors bind to the gp120 portion of the HIV envelope protein that makes up the spikes on the ...

HIV gets inside these cells by binding to the CD4 receptor using a molecule on the surface of the virus called gp120. Once HIV has bound to CD4, it activates other proteins on the surface of the human ...

The VRC01-class of potent, broadly neutralizing antibodies (bnAbs) targets the conserved CD4-binding site (CD4bs) of HIV-1 Env which has been a major target of HIV-vaccine design. The current best ...

这项发明的重要意义，同样体现在研发药物、诊治疾病方面。如艾滋病病毒表面突起蛋白gp120主要与人免疫T细胞表面蛋白结合，如果进一步确定gp120蛋白的结构，就可以设计出阻止其与T细胞结合 ...

Before fusion of the HIV viral envelope and host cell membrane can occur, an HIV glycoprotein complex consisting of glycoproteins gp41 and gp120 must bind with the CD4 receptor on the membrane of ...

2024年诺贝尔化学奖的颁发，再次将目光聚焦于人工智能的迅速发展与应用。在10月9日，瑞典皇家科学院宣布将本年度诺贝尔化学奖授予三位杰出科学家，其中一半授予戴维·贝克，另一半则共同授予德米斯·哈萨比斯和约翰·江珀。这一奖项不仅代表了对蛋白质研究的重大 ...

他们观察到Nb457通过与CD4结合，诱导了CD4的D1结构域构象改变，从而有效地阻碍了HIV-1的gp120与CD4细胞的结合。同时，他们发现Nb457的表位位于MHC-II结合位点的另一侧，避免了对MHC-II结合的干扰 ...

近年来，抗逆转录病毒疗法（ART）在抑制HIV复制方面取得了显著进展，显著延长了艾滋病患者的寿命，但该疗法同时也带来了严重的副作用，并导致大量耐药病例的出现。CD4作为HIV进入宿主细胞的主要受体，一直是HIV药物研发的重点靶点。然而，目前唯一的CD ...

The simple quantitation of HIV-specific antibody by ELISA or Western Blot after vaccination is not sufficient owing to the vast majority of this antibody being nonprotective. Thus assays must ...