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生物通
7 天
惊!短链脂肪酸或是 HIV 相关神经认知障碍的关键 “密码”,有望成 ...
短链脂肪酸(SCFAs)作为微生物群 - 肠 - 脑轴交流中的关键 “信使”,在中枢神经系统(CNS)疾病中有着不可忽视的作用。它可以调节炎症反应、神经元凋亡、氧化应激,还能维护血脑屏障(BBB)的完整性。在其他神经退行性疾病里,SCFAs 的表现十分亮眼。比如在 PD 患者中,粪便 SCFAs 水平明显低于健康人,而血浆 SCFAs 水平却有所升高,并且和疾病严重程度相关;AD ...
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