Through the deal, Celgene gains Gloucester's romidepsin (Istodax), a histone deacetylase (HDAC) inhibitor, which was approved by the FDA in November 2009 to treat cutaneous T cell lymphoma (CTCL ...

Concerns about HA-based HDAC inhibitors such as genotoxicity, rapid clearance and extensive metabolite formation, led CKD’s research team to identify a series of NHA molecules that selectively ...

Italfarmaco's marketing application for HDAC inhibitor givinostat as a treatment for Duchenne muscular dystrophy (DMD) has been accepted by the EMA, setting up an approval decision in 2024.

In contrast, in the new trial combining an HDAC inhibitor with the immunotherapy, 3 of 27 patients had deep tumor shrinkage from the drug combination. In future studies, the team hopes to ...

In contrast, in the new trial combining an HDAC inhibitor with the immunotherapy, 3 of 27 patients had deep tumor shrinkage from the drug combination. In future studies, the team hopes to ...

In a report released today, Edward White from H.C. Wainwright reiterated a Buy rating on Curis (CRIS – Research Report), with a price target of ...

Shuttle Pharmaceuticals Holdings, Inc. recently disclosed in an 8-K filing to the Securities and Exchange Commission that the company has started enrolling patients and administering doses at the UVA ...

REC-1245 is designed to degrade the protein RBM39, which downregulates cell cycle checkpoints and DNA damage response networks.