在细胞核内，HMGB1有助于DNA修复、染色体维持和细胞周期调节。一旦在细胞外释放，它就会与RAGE和TLR4等受体结合，放大炎症信号，并通过激活免疫细胞导致肝脏损伤。此外，HMGB1在自噬中发挥作用，自噬是细胞存活和肝组织再生不可或缺的过程。 受体和信号通路 ...

HMGB1's interactions with its primary receptors, RAGE and TLR4, are essential to its role in liver disease. Upon binding, these receptors initiate pro-inflammatory signaling pathways such as the ...

HMGB1 also contributes to autophagy, which is essential for liver tissue regeneration and cell survival. Upon binding with RAGE and TLR4, HMGB1 activates pro-inflammatory pathways that exacerbate ...