A sophisticated molecular machine, the spliceosome, ensures the accurate assembly of genetic information from the genome into mature mRNA after it has been transcribed into mRNA precursors.

Numerous sites of DNA damage are present on each heat-shocked spermatocyte nucleus. Image taken with a DeltaVision Ultra High Resolution widefield microscope. 3D modeling was done with Imaris ...

Torsional stress in chromatin plays a fundamental role in cellular functions, influencing key processes such as transcription, replication, and chromatin organization. Transcription and other ...

improving the lateral resolution of side-by-side features in images of the DNA molecule. WASHINGTON, Jan. 14, 2025 – Most microscopes can only illuminate objects down to a certain size before ...

This high-resolution structure presents a clear picture of how the MCM2-7 complex destabilizes DNA, giving rise to an initial opening of DNA duplex right at the juncture of the two coupled MCM2-7 ...