It has been proposed that APL pathogenesis relies in part on transcriptional silencing of RA target genes through the tethering by PML/RARα of stabilized corepressor-histone acetyl transferase ...

KAT6 is a histone lysine acetyl transferase involved in the epigenetic regulation of oncogenes and it is often dysregulated in cancer, including breast cancer. Inhibiting KAT6 blocks the transcription ...