The drug can sometimes cause life-threatening hyperkalemia, however, when used in combination with angiotensin-converting enzyme (ACE) inhibitors (which are also indicated for heart failure).

Hyperkalemia is a potentially serious condition that may be associated with numerous pathophysiological conditions. Clinically significant hyperkalemia reduces membrane excitability and disturbs ...

In the setting of ACE inhibitor-related hypotension, circumstances have evolved in such a way that peripheral resistance (and thereby BP) is dependent on angiotensin-II. As angiotensin-II is ...

Potassium (as chloride) 10mEq, 20mEq. Hyperkalemia. Chronic renal disease. Acute dehydration. Heat cramps. Severe tissue destruction. Adrenal insufficiency. Familial periodic paralysis. Acidosis ...

Olmesartan medoxomil, hydrochlorothiazide; 20mg/12.5mg, 40mg/12.5mg, 40mg/25mg; tabs. Olmesartan blocks the vasoconstrictor effects of angiotensin II by selectively blocking the binding of ...