The study examined one of these brakes, called MKP1—which the team found was expressed at lower levels in fibroblasts from ...

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease in ... express a receptor on their surface that promotes ...

with evidence of reduced expression among profibrotic proteins produced by basal-like cells and fibroblasts that contribute to the progression of IPF, including data from four biomarkers that were ...

with evidence of reduced expression among profibrotic proteins produced by basal-like cells and fibroblasts that contribute to the progression of IPF, including data from four biomarkers that were ...

Development of therapies that halt or reverse IPF and PAH progression is a significant unmet need. Improved diagnostic tools are essential for earlier detection and intervention in IPF and PAH.

Generative AI played a crucial role in developing ISM001-055, targeting TNIK for IPF treatment. Future studies are needed to further explore ISM001-055's potential in preventing IPF progression ...

There is ample evidence to justify investigating ET-1 blockade as a therapeutic approach in IPF. Data From Animal Studies. Transgenic mice with lung-specific overexpression of the human gene for ...

"Moreover, the profile of the statistically significant changes in the biomarkers in response to LTI-03 treatment also suggests that LTI-03 may not only act on fibroblasts, but also on epithelial ...