In obesity, B cells accumulate in white adipose tissue (WAT) and produce IgG, which may contribute to the development of glucose intolerance. IgG signals by binding to Fcγ receptors (FcγR ...

Over the past decade, several features of the B-cell receptor (BCR) complex have emerged as major markers for prognostic classification of B-cell chronic lymphocytic leukemia (B-CLL). In ...

Drugs that specifically inhibit BCR signaling elements are currently being tested in clinical trials. The promising results obtained so far suggest that in the near future we may have novel ...