Of these epigenetically labile targets, the transposable elements and imprinted genes are particularly important. Transposable elements and metastable epialleles. Most regions of the adult ...

Using advanced stem cell engineering techniques, researchers from the Chinese Academy of Sciences and Sun Yat-sen University targeted 20 key imprinting genes. These are the genes that regulate how ...

In the new study, mice were created through genetic editing of mouse embryonic stem cells targeting a class of mammal-specific genes known as imprinted genes, of which there are about 200, the ...

Sexual reproduction in mammals is a complex process. It involves a balance between the genetic material of both parents. A crucial mechanism, called genetic imprinting, plays a key role in this ...

Mammalian reproduction involves genomic imprinting, a process in which epigenetic modifications restrict the expression of certain genes to a single parental allele. The genes that are silenced or ...

Here, the investigators, led by corresponding author Wei Li of the Chinese Academy of Sciences (CAS) in Beijing, focused on targeting imprinting genes, which regulate gene expression in a number ...

The work has been reported in Cell Stem Cell. Gene imprinting refers to a process in which cells either express a gene from one parent, while the copy of that gene that is inherited from the other ...

A research group led by Wei Li at the Chinese Academy of Sciences has created mice born from two male parents and capable of reaching adulthood. This builds on previous work from the group in ...

Genomic imprinting is a mechanism that regulates gene expression based on parental origin, requiring every embryo to derive from a male gamete (sperm) and a female gamete (egg). "The unique ...

People with Prader-Willi syndrome still carry the requisite genes from their mother, but those genes are naturally silenced in healthy people through a mechanism called imprinting. “There are many ...

A team of scientists created a bi-paternal mouse through targeted imprinting gene edits in embryonic stem cells. This demonstrates the potential for overcoming barriers to unisexual mammalian ...