Using advanced stem cell engineering techniques, researchers from the Chinese Academy of Sciences and Sun Yat-sen University targeted 20 key imprinting genes. These are the genes that regulate how ...

To create mice with two fathers, the researchers targeted 20 of these imprinted genes in male embryonic stem cells, using CRISPR to delete or modify them. They then combined these edited cells ...

The work has been reported in Cell Stem Cell. Gene imprinting refers to a process in which cells either express a gene from one parent, while the copy of that gene that is inherited from the other ...

Until now, many similar attempts have resulted in unhealthy offspring. "The unique characteristics of imprinting genes have led scientists to believe that they are a fundamental barrier to ...

Genomic imprinting is a mechanism that regulates gene expression based on parental origin, requiring every embryo to derive from a male gamete (sperm) and a female gamete (egg). "The unique ...

What is genomic imprinting? Created with Sketch. Genomic imprinting is the biological mechanism wherein genes are expressed differently depending on whether they are inherited from the mother or ...

Mammalian reproduction involves genomic imprinting, a process in which epigenetic modifications restrict the expression of certain genes to a single parental allele. The genes that are silenced or ...

The latest advancement was made possible through the precise genetic engineering of imprinted genes, which are typically expressed from only one parental copy, while the other copy is silenced ...

A team of scientists created a bi-paternal mouse through targeted imprinting gene edits in embryonic stem cells. This demonstrates the potential for overcoming barriers to unisexual mammalian ...

The new approach focused on a particular set of genes, as per a press release. As "imprinting genes" regulate gene expression with “unique characteristics," scientists believe that they are a ...

In the new study, mice were created through genetic editing of mouse embryonic stem cells targeting a class of mammal-specific genes known as imprinted genes, of which there are about 200, the ...