The regulator HIF1α functions in a cancer-microenvironment that lacks oxygen, and it may be involved in resistance to immune ...

Why does the COVID-19 virus make some people sicker than others? For years, scientists have looked to a critical piece of ...

For years, scientists have looked to a critical piece of immune system machinery - known as the interferon pathway - for answers. There, when our cells sense an infection, they release a protein known ...

Inhibiting its activity increases T-cell recruitment and lowers tumor resistance to ... looking at more than 600 genes and their correlation with interferon-gamma, an anti-tumor gene that immune ...

University of Michigan researchers identified UBA1 as a key player in immunotherapy resistance. Inhibiting UBA1 boosts T-cell ...