Antibodies of the IgG4—but not the IgG1—isotype rapidly became bispecific in mice, most probably as a consequence of dynamic exchange between the two different IgG4 antibody half-molecules.

1 Department of Sport and Physical Rehabilitation Sciences, Tshwane University of Technology, Pretoria, South Africa 2 Department of Immunology, University of the Witwatersrand ... induced changes in ...