Researchers discover short form of a tumor-produced protein activates natural killer cells
A group of scientists in China has revealed a novel mechanism whereby a short form of IL-18, generated by caspase-3 cleavage in tumor cells, activates natural killer (NK) cells to suppress tumor ...
Nature20d
Clusterin contributes to caspase-3–independent brain injury following neonatal hypoxia-ischemia
Following neonatal H-I brain injury in mice (a model of cerebral palsy), there was evidence of apoptotic changes (neuronal caspase-3 activation), as well as accumulation of clusterin in dying neurons.