Gene targeting, also called knockout mouse technology, made it possible to conduct site-directed mutagenesis in a mammalian genome for the first time. Before 1990, gene targeting required a high ...

The Knockout Mouse Phenotyping Program (KOMP2) sites at Baylor College of Medicine, Jackson Laboratory, and University of California, Davis, are collaborating with the International Mouse Phenotyping ...

A knockout mouse is a laboratory mouse in which one or more genes have been turned off or "knocked out." To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene ...

Our core assists investigators with projects involving the production of transgenic, targeted knockout, and targeted knock-in mouse lines. Knockout and knock-in mouse lines can be generated using gene ...