SOS1 facilitates KRAS activation and influences downstream signaling pathways. Co-inhibiting SOS1 with KRAS may help to slow or inhibit the growth of cancer cells reliant on this pathway, by enhancing ...

Co-opted Pathways Required by Oncogenic KRAS to Sustain Lung Tumorigenesis Oncogenic KRAS relies on additional pathways that are engaged downstream of these effectors or are required indirectly as ...

But KRAS is no space station. It’s a lethal, misshapen protein that jumpstarts a pathway that drives almost a quarter of all cancers, and it has baffled scientists who have spent almost four ...

RTKs can activate Ras, a protein that is tethered to the plasma membrane, by causing it to bind GTP. Once activated, Ras can do a variety of things. In this example, it activates an enzymatic ...

The evidence for the authors' claims is convincing, combining state-of-the-art conditional gene deletion in the mouse lens with histological and molecular approaches. This work should be of great ...

Oncogenic KRAS activation is responsible for the most common genetic subtype of lung cancer. Although many of the major downstream signaling pathways that KRAS engages have been defined ...