Long-term dual antiplatelet therapy has not been rigorously assessed in patients with specific ischemic stroke subtypes other than that associated with atrial fibrillation (JW Neurol Aug 11 2009).

A large study of patients with acute stroke suggests that the substantial proportion who have acute lacunar stroke could have an underlying non-atherothrombic, occlusive, small-vessel disease ...

Although short-term dual antiplatelet therapy may eventually prove to benefit specific populations with very high stroke risk, the SPS3 trial definitively establishes that lacunar stroke alone is ...