This bioinformatics-assisted review describes key biological elements of known pathways, such as the forkhead box protein O1/leptin receptor and Janus kinase/signal transducer and activator of ...

Reiko Hanada; Hitoshi Teranishi; James Todd Pearson; Mamoru Kurokawa; Hiroshi Hosoda; Nobuhiro Fukushima; Yoshihiko Fukue; Ryota Serino; Hiroaki Fujihara; Yoichi Ueta ...

Current research focus in the Fukuda lab: Signaling mechanisms controlling neural leptin sensitivity A gut-brain signal that promotes obesity. A novel neural signaling pathway that may have an ...

These alterations lead to changes in neuronal communication, increased expression of inflammatory markers, and disruptions in ...

But in some individuals with obesity, this signaling system seems to malfunction—a condition known as leptin resistance, where high levels of leptin fail to curb hunger.