▎药明康德内容团队编辑（来源：武汉大学）急性髓系白血病（AML）是一种由造血干/祖细胞遗传异常引发的血液系统恶性肿瘤，其致病因素主要包括染色体易位和基因突变等遗传变异。除急性早幼粒细胞白血病外，AML普遍存在治疗手段有限、复发率高、死亡率高等问题，导 ...

In the following study, we present the dynamics of the VAFs of somatic variants across different disease stages and demonstrate correlations between associated biological pathways and leukemic ...

Leukemic stem cells (LSCs) and stemness signatures contribute to minimal residual disease in patients with acute myeloid leukemia (AML), which is associated with an increased risk of relapse. The ...

Metformin significantly blocks cell cycle and inhibits cell proliferation and colony formation of leukemic cells. However, the apoptotic response to metformin varies. Furthermore, daily treatment ...

"We found that using leukemic cell lines can lead to misleading results in drug discovery," said Wilhelm. "These cell lines do not grow in the same way as cells taken from patients." The efficacy ...

The mechanisms of HSC maintenance are hijacked during the leukemogenic transformation of hematopoietic stem/progenitor cells into a rare population known as leukemic stem cells (LSC) or ...

The Kharas lab is working to identify critical pathways in both normal and leukemic hematopoietic cells. MSK investigators have used a lab tool originally developed to study fly nerve cells to uncover ...

Introduction: A unique feature of chronic lymphocytic leukemia (CLL) is the increased number of circulating T cells preventing malignant B cells from undergoing apoptosis. Dysregulated expression of ...