In this illustrative study, we used MDA-MD-468LN and ΔVEGF-D/468LN cells to examine the role of VEGF-D expression by tumor cells on tumor-induced lymphangiogenesis in vivo. VEGF-D secretion (24 ...

The functional lymphatic vessels transport inflammatory lymph-carrying inflammatory cells, catabolic factors and cytokines to the draining LNs and promote lymphangiogenesis, leading to an ...

In a mouse corneal angiogenesis assay, FGF-2 stimulates both lymphangiogenesis and angiogenesis. FGF-2 upregulates VEGF-C expression in vascular endothelial and perivascular cells. Anti-VEGFR-3 ...

When a tumour develops, it creates a structure around itself called the tumour stroma, within which blood and lymphatic vessels ensure nutritional and respiratory biological exchanges.

When a tumor develops, it creates a structure around itself called the tumor stroma, within which blood and lymphatic vessels ensure nutritional and respiratory biological exchanges. Lymphangiogenesis ...

We do biomedical research in vascular biology with a focus on lymphangiogenesis and the VEGF family of growth factors. Blood and lymphatic vessels play important roles in almost all major human ...

Lymphangiogenesis, i.e. the development of lymphatic vessels, is generally associated with a poor prognosis, as it favours the spread of metastases to other organs. By studying the cells that make ...