Scientists have gained a deeper understanding of a molecule that regulates lipid levels in the brain. This breakthrough could ...

Using a staining method for acid phosphatase, de Duve and Novikoff confirmed its location in the lysosome using light and electron microscopic studies (Essner & Novikoff 1961). Nowadays ...

Soluble proteins are carried in the lumens of vesicles. Any proteins that are destined for a lysosome are delivered to the lysosome interior when the vesicle that carries them fuses with the ...

McMaster University researchers have discovered a previously unknown cell-protecting function of a protein, which could open ...

The ability to therapeutically manipulate the immune system presents a multitude of potential opportunities for treating ...

Autophagy can also occur at a whole cell level, where entire cells are destroyed. However, if the lysosome itself becomes ...

Notably, TFEB and TFE3 are present across the animal kingdom, indicating that STING-induced autophagy-lysosome pathway is more evolutionarily ancient than its inflammation function, which is only ...

Furthermore, they found that downregulation of BAG3, a protein involved in protein clearance through the autophagy-lysosome ...

Findings indicate BAG3 modulation after traumatic brain injury may mitigate tau buildup and cognitive deficits, presenting a ...

Each year, about 2.5 million people suffer from traumatic brain injuries (TBI), which often increases their risk of ...