Cytotoxic T lymphocytes (CTLs) recognize peptides from foreign antigens that are presented by major histocompatibility complex (MHC) class I molecules. Antigens are degraded in the cytosol by ...

This finding supports the idea that antigenic peptides are derived from ‘freshly made’ proteins. TAP–GFP motility was also correlated with the transport of MHC class I molecules from the ER ...

Our core provides customized MHC/peptide tetramers for identification of antigen-specific T lymphocytes by flow cytometry. Tetramers and/or their derivatives are provided for research purposes only.

T cells use the T cell antigen-receptor (TCR) to recognize their antigens, which are often in the form of peptides bound to major histocompatibility complex molecules (MHC), also called HLA (human ...

Cancer treatment has entered a revolutionary phase with advancements in immunotherapy, a field that employs the immune system ...

An intracellular sensor that tracks the quality of so-called MHC-I molecules which aid the immune system in identifying and ...