They are highly plastic, and rapidly under phenotype switch in response to external stimuli. Macrophages have evolutionarily conserved functions including phagocytosis, migration, and antigen ...

Studies to date have produced varying results, reflecting varying chemical compositions of different e-liquids. Chronic tobacco smoking is known to alter macrophage function, resulting in impaired ...

Objectives To study macrophage functions in SSc with a focus on Fosl-2 as a potential regulator. Conclusion For the first time, we showed an increased expression of Fosl-2 and boosted phagocytic ...

COPD patients experience chronic inflammation and defective innate immunity, largely driven by macrophage dysfunction. In established disease, COPD macrophages have impaired phagocytosis of bacteria ...

One of the key findings from this research is that when macrophage identify antibodies on the surface of a cancer cell, they don't immediately begin phagocytosis. Instead, they first rearrange the ...

Mechanistically, genetic ablation or pharmacological inhibition of DYRK1B strongly attracts tumoricidal macrophages and, in addition, downregulates the phagocytosis checkpoint and ‘don’t eat me’ ...