“The platform has enabled us to develop a pipeline of novel therapeutic programs, targeting tumor-associated macrophages, based on either first-in-class targets or first-in-mechanism ...

Abnormal macrophage behaviour is also seen in fibrotic ... tissue regenerating or immune-suppressive.” Likely disease targets will be inflammatory bowel disease, uric formation, and lupus.

Researchers at Duke-NUS Medical School have identified YAP and TAZ proteins as key drivers of pulmonary fibrosis. Blocking ...

A discovery offers new hope in the battle against pulmonary fibrosis, a debilitating lung condition that progressively makes it harder for patients to breathe. Scientists have pinpointed proteins in ...

Macrophages interact with T cells in order to bring about T cell activation in target organs, and are themselves activated by inflammatory messenger molecules (cytokines) produced by the T cells.

The $4.9 billion acquisition of Forty Seven by Gilead is an example of the explosive excitement and investment into macrophage-directed therapies, utilizing CD47 checkpoint blockades ...

A discovery at Duke-NUS Medical School offers new hope in the battle against pulmonary fibrosis, a debilitating lung condition that progressively makes it harder for patients to breathe. Scientists ...

Meghan Morrissey wants to understand how macrophages measure, add and subtract all the signals they receive to calculate their response to a target. We use high resolution live imaging, synthetic ...

Researchers have identified YAP and TAZ as crucial regulators of macrophage-mediated pulmonary inflammation and fibrosis, ...

Joint injury induces rapid and sustained diversification of resident and infiltrating synovial macrophage phenotypes, underpinning osteoarthritis-associated synovitis.