Methylation is the addition of methyl chemical groups to nucleotide bases in a strand of DNA. The marks influence which genes are expressed or what levels they’re expressed at. Most methylation occurs ...

Addition of a methyl group to cytosine is associated with stable and heritable repression of transcription. Finding genes and genomic regions that are silenced during development or disease ...

Tyr 34 also accepts a hydrogen bond from the 4-amino group of one of the methylated cytosine residues, further contributing to sequence selectivity. The crucial nature of the contacts between ...

Cytosine can undergo chemical modifications that play crucial roles in gene regulation and epigenetics. The most common modification is the addition of a methyl group to carbon 5, forming ...

This 1:1 ratio of A:T and G:C is crucial for maintaining the structure and stability of DNA. 5-Methylcytosine is a modified nucleobase formed by the enzymatic addition of a methyl group to the 5th ...

The latter is called an epigenetic alteration. While cytosine methylation is a healthy process, methylation of promoter CpG islands has also been shown to be a critical hallmark in many cancer cells.