Genetically-modified hematopoietic cells enter the CNS and differentiate into microglia after bone-marrow transplantation. Up to a quarter of the regional microglial population is donor-derived by ...
The brain contains many cell types, from the prominent neurons to the lesser-known microglia. The latter are integral to the ...
In healthy brains, immune cells called microglia patrol for damage, clearing away debris and harmful proteins. But in the presence of the APOE4 protein—the most important genetic risk factor for ...
Researchers have unraveled how immune cells called microglia can transform and drive harmful processes like neuroinflammation in Alzheimer's disease. The study also integrates drug databases with real ...
Cleveland Clinic Genome Center researchers have unraveled how immune cells called microglia can transform and drive harmful processes like ...
Scientists report on new insights into the mechanisms of 'Niemann-Pick type C' (NPC), a rare neurodegenerative disease associated with dementia that can manifest as early as childhood. Their findings, ...
University of Washington-led research, published in 2023, discovered microglia in the brains of people with Alzheimer's ...
In an article published in the journal Science Translational Medicine, scientists from DZNE and LMU Hospital report on new ...
A decline in motor skills is a hallmark of Parkinson's disease, regularly taking the form of slowness, rigidity, and tremors.
This valuable study investigates the signaling pathways regulating retina regeneration. Solid evidence shows that the sphingosine-1-phosphate (S1P) signaling pathway is inhibited following retinal ...