Researchers have unraveled how immune cells called microglia can transform and drive harmful processes like neuroinflammation in Alzheimer's disease. The study also integrates drug databases with real ...
Genetically-modified hematopoietic cells enter the CNS and differentiate into microglia after bone-marrow transplantation. Up to a quarter of the regional microglial population is donor-derived by ...
In healthy brains, immune cells called microglia patrol for damage, clearing away debris and harmful proteins. But in the presence of the APOE4 protein—the most important genetic risk factor for ...
More information: Antara Rao et al, Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer's disease model, Cell Stem Cell (2024). DOI: 10.1016/j.stem.2024.10.005 ...