Researchers have unraveled how immune cells called microglia can transform and drive harmful processes like neuroinflammation in Alzheimer's disease. The study also integrates drug databases with real ...
Genetically-modified hematopoietic cells enter the CNS and differentiate into microglia after bone-marrow transplantation. Up to a quarter of the regional microglial population is donor-derived by ...
Cleveland Clinic Genome Center researchers have unraveled how immune cells called microglia can transform and drive harmful processes like ...
In an article published in the journal Science Translational Medicine, scientists from DZNE and LMU Hospital report on new ...
University of Washington-led research, published in 2023, discovered microglia in the brains of people with Alzheimer's ...
In healthy brains, immune cells called microglia patrol for damage, clearing away debris and harmful proteins. But in the presence of the APOE4 protein—the most important genetic risk factor for ...
More information: Antara Rao et al, Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer's disease model, Cell Stem Cell (2024). DOI: 10.1016/j.stem.2024.10.005 ...
A decline in motor skills is a hallmark of Parkinson's disease, regularly taking the form of slowness, rigidity, and tremors.
In the journal "Science Translational Medicine", scientists from DZNE and LMU Hospital report on new insights into the ...