News Medical on MSN1mon
Studies uncover mechanisms behind micronuclear instability and cancer progression
Similar to the companion study, Martin et al. found that ROS from nearby mitochondria causes p62 to aggregate, making the ...
Frontiers4y
Mitochondrial Dysfunction, Mitophagy & Autophagy in Alzheimer's Disease
Intriguingly, abnormal regulation of mitochondrial division protein Drp1 directly causes in forming Tau tangles inside the neurons, also regulates mitophagy proteins such as PINK1, Optineurin, p62, ...
BMJ6mon
A1.23 IFNα mediated deregulation of mitochondrial DNA clearance as an inciting event for the development of SLE autoimmunity
LC3 and P62. Autoreactivity was assayed in MLRs and assessed by ELISA for IL6 and TNFα and flow cytometry for HLADR, CD86 and Tcell CFSE dillution. Autophagolysosomal pH, mtROS production, ...
BMJ10mon
Mitophagy is impaired in MELAS
Results Mitochondrial biogenesis was not increased in MELAS cybrids. Basal LC3-II/LC3-I ratios and p62 levels (markers of macroautophagy) were increased in MELAS cybrids. On induction and subsequent ...
The EMBO Journal5d
Autophagy adaptors mediate Parkin-dependent mitophagy by forming sheet-like liquid condensates
During PINK1- and Parkin-mediated mitophagy, autophagy adaptors are recruited to damaged mitochondria to promote their selective degradation. Autophagy adaptors such as optineurin (OPTN) and NDP52 ...
BMJ1mon
Autophagy is activated in systemic lupus erythematosus and required for plasmablast development
Mouse cells were incubated with monoclonal rabbit anti-p62 1:500 (clone D10E10) (Cell Signaling Technology, USA), washed, and then incubated with DyLight 649-goat anti-rabbit secondary antibody (Abcam ...