Thus, in order for a particular cell to become cancerous, both of the cell's tumor suppressor genes must be mutated. This idea is known as the "two-hit" hypothesis, and it was first proposed by ...

MD The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the ...

p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

Working together, the four of us made compelling discoveries in studying p53, a tumor suppressor gene that is mutated in more than half of all tumors. Our findings clarified how p53 normally induces ...

Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...

Table 2. Associations of brown fat, obesity and loss/mutation of tumor suppressor genes in endometrial and breast cancer. † P53 mutation in case of PTEN or BRCA1 mutation. ‡ Brown fat state in ...

It is caused by mutations in a large number of genes that are acquired in the course of a person's life. One of these genes—the tumor suppressor gene TP53—plays a key role. Normally, TP53 ...

Ten years later, it changed from an oncogene to a tumor suppressor gene. And that just changed the field completely ... Scientists made these findings as the theory of oncogenes, the idea that mutated ...