Thus, in order for a particular cell to become cancerous, both of the cell's tumor suppressor genes must be mutated. This idea is known as the "two-hit" hypothesis, and it was first proposed by ...

MD The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the ...

Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...

These findings provide evidence that promoter methylation of Dkk-3 is a common event in gastric cancer and that Dkk-3 is a tumor suppressor gene through the inhibition of Wnt signaling.

It is caused by mutations in a large number of genes that are acquired in the course of a person's life. One of these genes—the tumor suppressor gene TP53—plays a key role. Normally, TP53 ...

Table 2. Associations of brown fat, obesity and loss/mutation of tumor suppressor genes in endometrial and breast cancer. † P53 mutation in case of PTEN or BRCA1 mutation. ‡ Brown fat state in ...

Earlier studies had suggested that these drugs, known as DNA methyltransferase inhibitors (DNMTis), worked by triggering the expression of tumor suppressor genes. But Chiappinelli, then a postdoctoral ...

A study published in Science Advances reveals a novel strategy that allows tumors to evade the body’s immune response ...

Ten years later, it changed from an oncogene to a tumor suppressor gene. And that just changed ... Scientists made these findings as the theory of oncogenes, the idea that mutated host ...

Working together, the four of us made compelling discoveries in studying p53, a tumor suppressor gene that is mutated in more than half of all tumors. Our findings clarified how p53 normally induces ...

"Chemotherapy has had limited efficacy as a first-line treatment in controlling the aggressive tumor growth we see in patients with this mutation," said co-principal investigator Scott Kopetz ...