NK cells recognize cell-bound antibodies via CD16A (FcγRIIIA) to mediate antibody-dependent cellular cytotoxicity (ADCC). Potentiating therapeutic mAb-mediated CD16 activation of NK cells is an ...

Source: Sino Biological Inc. To mediate antibody-dependent cellular cytotoxicity (ADCC), NK cells recognize cell-bound antibodies via CD16A (FcγRIIIA). A new area of cancer immunotherapy is ...

For solid tumors and hematological malignancies, CAR-NK cell treatment is a novel kind of cancer immunotherapy. CAR-NK cells work by killing cancer cells in a CAR-dependent way. CAR-NK cells and ...

a subset of NK cells bearing the activating Ly49H receptor, which specifically binds the viral glycoprotein m157, can proliferate 100-1000 fold in lymphoid and non-lymphoid organs following mouse ...

CAR-NK therapy involves modifying NK cells using ... “But importantly, you also activate memory T cells. With this, if you can activate the immune system, then, once you’ve stopped the ...

NK cells and gamma delta (γδ) T-cells – are activated to directly attack and kill tumor cells upon contact, while critically shaping the overall tumor microenvironment to be more permissive to ...

Dragonfly's TriNKET compounds are designed to activate and direct NK and cytotoxic T cell killing against cancer cells. The platform has also attracted partnerships from other pharma groups ...

so need to be activated before they attack cancer cells that present antigens. NK cells are part of the innate immune system, a first line of defense that doesn't need to be primed into action.