Natural killer (NK) cells are key innate immune lymphocytes, which play important roles against tumors. However, ...

Natural killer (NK) cells play an important role in the innate immune response to cancer and viral infections, and their ...

In multicellular organisms, the total number of cells is a balance between the cell-generating effects of mitosis and cell death that is induced through apoptosis. A disruption of this delicate ...

Thus, in order totreat cutaneous malignancies such as melanoma-or squamous-cell carcinoma with recombinant Apo2L/TRAIL (ref. 7), it is critically important not to trigger premature apoptosis of ...

Intracellular checkpoint molecules like BIM, which mediates apoptosis in NK cells, can be targeted to enhance antitumor responses. The absence of BIM in NK cells has been shown to increase their ...