namely autophagic cell death, necroptosis and poly (ADP–ribose) polymerase-1 (PARP1)-mediated cell death. Emerging data provided the first insights into the cellular regulation of these processes.

cells, especially M4 and M5 subtypes, produce TNF and show basal level activation of RIP1/RIP3/MLKL signaling, yet do not undergo necroptosis. TNF, through RIP1/RIP3 signaling, prevents ...

A cell in yellow is shown dying by necroptosis, a process requiring the protein MLKL Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert!