Because p62, one of the adaptors involved in directing substrates for autophagic degradation, has a ubiquitin-binding domain, researchers focused on ubiquitin as a sorting signal in autophagy.

α-Synuclein amyloid fibril directly binds to LC3B and suppresses SQSTM1/p62-mediated selective autophagy 的论文。 该研究深入探讨了帕金森病病理蛋白α-syn聚集体与自噬 ...

经药物处理后，自噬标记物表达水平有变化，p62蛋白水平降低（A和B图），LC3-II水平上升（C图） Screen-well™ Autophagy Library是研究促自噬和抗自噬分子的有力工具。化合物库中包含96种已知的自噬诱导剂或者抑制剂，可作用于与自噬相关的蛋白或受体，包括 ...

By Dr. Liji Thomas, MD Study finds that consuming more caffeine may improve heart health. Study: Caffeine improves systemic ...

A research team has discovered a novel mechanism essential for initiating autophagy. The study highlights the role of ZDHHC13, an enzyme that palmitoylates ULK1, in triggering autophagy.

近日，中国科学院上海有机化学研究所生物与化学交叉研究中心刘聪研究员、谭立研究员与中国科学技术大学项晟祺教授合作，在 Journal of the American Chemical Society 发表了题为 “Inhibitor Development for α?Synuclein Fibril’s Disordered Region to Alleviate Parkinson’s Dise ...

NRF1 plays a critical role in the formation of p62-positive puncta, facilitating the aggregation of p62 proteins after proteasome inhibition. This process is crucial for the efficient clearance of ...

Autophagy is a natural regeneration process that occurs at a cellular level in the body, reducing the likelihood of contracting some diseases as well as prolonging lifespan. In 2016, Japanese ...

A mouse xenograft model of DLBCL tumors was used to characterize the role of TNFAIP3 expression tumor growth. Tumors induced from cells with higher levels of TNFAIP3 had a lower volume compared with ...

Autophagy is a process by which cells break down and recycle their own components to maintain homeostasis. The research team scrutinized the autophagy process in astrocytes and discovered that ...

Using an amino acid depleted media, we can induce autophagy without apoptosis during myogenesis in vitro. We have characterized the histone methylation profiles affected by this cell phenotype switch ...