Postmortem examination showed extensive organ fibrosis, including severe diffuse alveolar damage and parenchymal fibrosis, and a notable lack of potentially treatable tissue inflammation.

Non-parenchymal cells like hepatic stellate cells (HSCs), Kupffer cells (KCs), and liver sinusoidal endothelial cells (LSECs) play a key role in fibrosis development. These cells are involved in ...

Moreover, the cells and soluble factors participating in this response in liver are also similar to those in parenchymal injury to kidney, lung, or skin. Fibrosis occurs earliest in regions where ...

The UAB ILD Center offers clinical trial enrollment for patients with idiopathic pulmonary fibrosis and other forms of diffuse parenchymal lung disease as part of a multidisciplinary and integrated ...

In response to chronic stimuli such as alcohol abuse, viral infection, NAFLD/NASH and toxic damage, liver loses its normal structure and non-parenchymal cells including HSCs, KCs and LSECs undergo ...

Comparison of idiopathic pulmonary fibrosis versus sarcoidosis and systemic sclerosis (↑: upregulated in idiopathic pulmonary fibrosis). § Study on carbonylated proteins by western blot.