CRISPR screening is an application of this technology, and we can do the screens in two ways. Our pooled format takes huge numbers of lentiviral guide RNAs and delivers them to a large population ...

The findings also reveal a potential limitation of pooled CRISPR screens in studying parasite biology in live hosts. The study was lead by authors Francesca Torelli and Diogo M. da Fonseca ...

A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on DNA replication. KDM1A promotes survival in DAC-treated cells via DNA ...

A library of guide RNAs—each targeting a unique gene for CRISPR-based interference and carrying a unique barcode sequence—is introduced into a population of cells at a concentration that results in ...

In their article published in Nature Methods, the researchers applied PERISCOPE to execute three whole-genome CRISPR screens to create ... to analyze optical pooled screening data at scale." ...

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