Patients with severe lupus nephritis who have both diffuse proliferative (class IV) and membranous (class V) lesions on biopsy can be refractory to current monotherapy treatments. Bao et al.

Adding obinutuzumab to standard therapy for active lupus nephritis led to significantly higher rates of complete renal ...

1 The purpose of ALMS was to demonstrate the superiority of mycophenolate mofetil (MMF) over intravenous cyclophosphamide for the induction of remission in patients with lupus nephritis.

Thus, lupus nephritis can be diagnosed and treated ... to be treated with antiproliferative agents. Second, severe proliferative nephritis takes time to heal. Nephrologists are aware from their ...

Systemic lupus erythematosus is a complex autoimmune disorder affecting multiple organ systems. Glomerulonephritis leading to severe proteinuria, chronic renal failure and end-stage renal disease ...

So class III lupus is focal proliferative lupus nephritis where fewer than 50% of glomeruli are involved by light microscopy. And class IV is a diffuse proliferative lupus nephritis where greater ...

Obinutuzumab B-cell depleting therapy is more effective than standard care in treating patients with active proliferative lupus nephritis.