Vane's contributions include showing that one of the world's most widely used drugs — aspirin — acts to relieve pain, fever and inflammation by blocking the production of prostaglandins.

Prostaglandins (PGs ... thereby facilitating the outflow of aqueous humor from the eye. Clinically used PGs are PGF 2α analogs which bind to PGF receptors to influence matrix metalloproteinase ...

The recent finding that cyclopentenone prostaglandins inhibit IκB kinase provides a new explanation for the anti-inflammatory effects of these molecules. However, inhibition of prostaglandin ...