NRF1 plays a critical role in the formation of p62-positive puncta, facilitating the aggregation of p62 proteins after proteasome inhibition. This process is crucial for the efficient clearance of ...

The final 20S proteasome product looks less like cartoon mechanized lions forming a microscopic Voltron and more like a humble barrel, albeit just as destructive to proteins targeted for recycling ...

Developing small molecules that activate a subset of the body’s proteasomes to degrade defective proteins could be an effective way to treat neurodegenerative diseases and other complex ...

The proteasome is a large protein complex in the cytoplasm of eukaryotic and archaeal cells responsible for proteolysis of proteins that have one or more poly-ubiquitin post-translational ...

More information: Jin Ju Lim et al, Pharmacological inhibition of USP14 delays proteostasis-associated aging in a ...

In this vein, a research team from Korea set out to investigate the relationship between two essential protein quality control systems, namely proteasomes and autophagy. The researchers led by ...