Phosphoinositides recruit proteins to distinct intracellular membranes. Now, the Phox homology (PX) domain, an evolutionarily conserved protein domain whose function has so far been elusive ...

The TRIM (tripartite motif-containing) family of proteins is defined by an amino-terminal set of domains that is known as the RBCC (RING, B-box, coiled-coil) motif. The RBCC motif can exist in ...

2024年诺贝尔生理学或医学奖授予科学家维克托·安布罗斯（Victor Ambros）和加里·鲁夫昆（Gary Ruvkun）。 今年诺奖看似冷门，其实和你的健康息息相关。 这一次诺贝尔生理学或医学奖，又是「发现第一人+深度研究」组合。

武汉大学生命科学学院在读博士研究生赵闪及美国NIH国家医学图书馆Kira Makarova博士为该论文的共同第一作者，郑文超和刘雅菲等研究生深入参与了研究，杜世燊研究员与Eugene V.

引言膜蛋白是细胞生命活动中至关重要的分子，它们不仅参与物质运输、信号传导，还帮助维持细胞的结构稳定性。在多种细胞类型中，尤其是上皮细胞，膜蛋白的极性排序确保了细胞的正常功能发挥。一个典型的例子是肠道上皮细胞，它们在吸收和分泌过程中依赖于膜蛋白的极性排 ...

Science is filled with tools that once seemed revolutionary and are now just part of the research tool kit. That time may ...

Explore a novel approach of structural analysis using Microfluidic Modulation Spectroscopy, offering insights into protein ...

Scientists have identified a protein that blocks the activity of bone-forming cells (osteoblasts) by stopping them from ...

In the ongoing effort to enhance crop efficiency, researchers have uncovered key genetic components of photosynthesis in ...

Researchers at LMU University Hospital have discovered a new molecular switch that protects against cell death.

The role of the C-type lectin domain containing 14A (Clec14a), a type-H endothelial protein, in coordinating osteoblast ...

戊烯基是一种疏水的五碳片段，在生物化学和天然产物化学中广泛存在。具有广泛药用价值的天然产品——多环聚戊烯基酰基间苯三酚（PPAPs），一直是多个合成研究的目标，但不对称地引入戊烯基已被证明是一个持久的挑战。 Ng等人报道了一种铜催化的方法，使不饱和酮戊酰化，从而获得具有高对映选择性的PPAP。该方法的关键是一种有机硼酸盐试剂，硼在一个有点违反直觉的位置。