Both classification schemes are based on a hierarchy of fold types. At the top level are all alpha proteins (domains consisting of alpha helices), all beta proteins (domains consisting of beta sheets) ...

Please note: repository in WIP, each folder indicated by WIP will be updated soon. All protein domains analysis follows the data from Interpro version 75.0. All data ...

Phosphoinositides recruit proteins to distinct intracellular membranes. Now, the Phox homology (PX) domain, an evolutionarily conserved protein domain whose function has so far been elusive ...

Here, we propose a new method called Domain2GO with the aim of identifying unknown protein functions by associating domains with Gene Ontology terms, thus defining the problem as domain function ...

The TRIM (tripartite motif-containing) family of proteins is defined by an amino-terminal set of domains that is known as the RBCC (RING, B-box, coiled-coil) motif. The RBCC motif can exist in ...

In the ongoing effort to enhance crop efficiency, researchers have uncovered key genetic components of photosynthesis in ...

The CFTR Protein Production Core is supported and administered by ... Structural stability of purified human CFTR is systematically improved by mutations in nucleotide binding domain 1. Biochim ...

The C-terminal BON domain binds anionic phospholipids through an extensive membrane:protein interface. This interaction is essential for DolP function and is required for sub-cellular localisation of ...

Hsp70 solubilizes aggregates and aids protein refolding through substrate binding and release cycles regulated by co-chaperones: J-domain proteins (JDPs) and Nucleotide Exchange Factors (NEFs). Here, ...

Our data indicate that the fundamental regulators of transcription and chromatin remodeling, rather than interaction with NL proteins, play a major role in transcription regulation within LADs. Lamina ...