Discover how next-generation kinase inhibitors are transforming clinical therapy byovercoming resistance and enhancing ...

A new review published in Genes & Diseases explores the multifaceted role of FAM20C, a Golgi protein kinase, in disease ...

This content introduces the physiological and pathological importance of protein kinases, kinase inhibitors approved for ...

Protein kinase C (PKC) is as a family of serine/threonine kinases that can be activated by Ca 2+, phospholipid and diacylglycerol. PKC plays an important role in oocyte maturation and activation.

A new review published in Genes & Diseases explores the multifaceted role of FAM20C, a Golgi protein kinase, in disease progression.

In cancers, all translocations involving ALK produce fusion proteins with constitutive tyrosine kinase activity that in most cases derives from spontaneous dimerization induced by the different ...

Mammalian hosts coordinate various cell death pathways as part of the immune defense system against pathogens including ...

One of these proteins is pantothenate kinase 4 (PanK4). In order to understand how PanK4 influences energy metabolism in skeletal muscles, Kleinert and his team used various genetic mouse models ...

Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.

Cystic fibrosis is a life-threatening disease predominantly with respiratory symptoms. Most of the subjects with the disease harbor the F508del variant in the CFTR gene that causes the protein to ...