A research group of The University of Tokyo has discovered that in mammals, a protein kinase A (PKA) promotes wakefulness, ...

Recent research has observed that chemical modifications called phosphorylation of proteins in brain neurons dynamically ...

生命科学Life science2024年11月21日，中山大学孙逸仙纪念医院蒋琳加研究员在Cell Press细胞出版社旗下期刊Trends in Cell Biology杂志发表了题为 “Targeting SHP1 and SHP2 to suppress tumors and enhance immunosurveillance”的综述文章。SHP1和SHP2是非受体蛋白酪氨酸磷酸酶（no ...

Here we show that a regulator of synaptic plasticity, calcium/calmodulin-dependent protein kinase IIα ... secondary autophosphorylation and phosphatase 1 action. Once dissociated, CaMKII shows ...

and dephosphorylation (catalyzed by protein phosphatases). Protein kinases mediate most of the signal transduction events in cells by phosphorylation of specific substrates - modifying their activity, ...