【导读】蛋白水解靶向嵌合体（PROteolysis TArgeting Chimeras, PROTACs）被认为是下一个重磅疗法。然而，由于其固有的局限性，PROTACs的疗效经常受到组织穿透能力有限以及其作用部位的细胞内化不足的影响。10月18日 ...

Proteolysis is the enzymatic process by which proteins are degraded into their component polypeptide or amino acid parts. This generally occurs through protease-mediated hydrolysis of peptide ...

Currently There Are More Than 50 PROTAC Drugs In Clinical Trials And Majority Are For Cancer As Per Recent Study By Kuick ...

First PROTAC Drug Is Expected To Enter The Market By 2027 Says Kuick In New StudyDelhi, Oct. 11, 2024 (GLOBE NEWSWIRE) -- ...

BioTheryX’s technology platform centers on targeted protein degradation, including PHM ‘molecular glues’, PROteolysis TArgeting Chimeras (PROTACs/PTCs) and monovalent degraders that enable ...

Signal transduction across membranes through regulated intramembrane proteolysis is conserved throughout all domains of life. In the SREBP pathway of human cells, the membrane-bound SREBP ...