【导读】蛋白水解靶向嵌合体（PROteolysis TArgeting Chimeras, PROTACs）被认为是下一个重磅疗法。然而，由于其固有的局限性，PROTACs的疗效经常受到组织穿透能力有限以及其作用部位的细胞内化不足的影响。10月18日 ...

Proteolysis is the enzymatic process by which proteins are degraded into their component polypeptide or amino acid parts. This generally occurs through protease-mediated hydrolysis of peptide ...

人体内大约有20000种蛋白质。其中，超过600种已被发现与各类癌症的发病密切相关。对于创新药企而言，精准地理解这些蛋白质及其在癌症中的作用，并据此进行有效的干预，是新药研发的关键思路。最常见的一种干预机制，被称为“占据驱动”（occupancy-d ...

Save the Sound: Members of Arvinas helped preserve the Long Island Sound and Greater New Haven area by collecting over 287 pounds of trash, contributing to efforts to protect local wildlife and ...

Currently There Are More Than 50 PROTAC Drugs In Clinical Trials And Majority Are For Cancer As Per Recent Study By Kuick ...

微成都记者 孙树冠10月15日报道，今日，海创药业（688302.SH）公告称，收到中国国家药品监督管理局药品审评中心核准签发的《药物临床试验批准通知书》，同意HP568片开展用于治疗雌激素受体（Estrogen Receptor, ...

First PROTAC Drug Is Expected To Enter The Market By 2027 Says Kuick In New StudyDelhi, Oct. 11, 2024 (GLOBE NEWSWIRE) -- ...

BioTheryX’s technology platform centers on targeted protein degradation, including PHM ‘molecular glues’, PROteolysis TArgeting Chimeras (PROTACs/PTCs) and monovalent degraders that enable ...

Despite past performance issues, Arvinas has a solid cash runway. Learn more about ARVN stock's potential and why a cautious ...

Signal transduction across membranes through regulated intramembrane proteolysis is conserved throughout all domains of life. In the SREBP pathway of human cells, the membrane-bound SREBP ...

上证报中国证券网讯 海创药业 10 月15日晚披露，公司近日收到中国国家药品监督管理局药品审评中心核准签发的《药物临床试验批准通知书》，同意HP568片开展用于治疗雌激素受体（Estrogen Receptor, ER）阳性和人表皮生长因子受体 2（Human Epidermal Growth Factor Receptor, ...

Biotechnology Co. Ltd. has disclosed proteolysis targeting chimeras (PROTACs) comprising a cereblon (CRBN) ligand coupled to a mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1; HPK1; ...